Tackling influenza with broadly neutralizing antibodies
Identifieur interne : 000268 ( Main/Exploration ); précédent : 000267; suivant : 000269Tackling influenza with broadly neutralizing antibodies
Auteurs : Davide Corti [Suisse] ; Elisabetta Cameroni [Suisse] ; Barbara Guarino [Suisse] ; Nicole L. Kallewaard [États-Unis] ; Qing Zhu [États-Unis] ; Antonio Lanzavecchia [Suisse]Source :
- Current Opinion in Virology [ 1879-6257 ] ; 2017.
Abstract
Broadly neutralizing antibodies against influenza A and B represents a safe and affordable alternative to convalescent plasma. The large majority of broadly neutralizing antibodies target the stem region of HA. Antiviral protection by anti-HA antibodies comprises both Fab- and Fc-dependent mechanisms. Several broadly neutralizing antibodies are in development for the therapy of severe influenza infections.
Url:
DOI: 10.1016/j.coviro.2017.03.002
PubMed: 28527859
PubMed Central: 7102826
Affiliations:
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Kallewaard</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhu, Qing" sort="Zhu, Qing" uniqKey="Zhu Q" first="Qing" last="Zhu">Qing Zhu</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28527859</idno><idno type="pmc">7102826</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102826</idno><idno type="RBID">PMC:7102826</idno><idno type="doi">10.1016/j.coviro.2017.03.002</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000D19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D19</idno><idno type="wicri:Area/Pmc/Curation">000D19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D19</idno><idno type="wicri:Area/Pmc/Checkpoint">000192</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000192</idno><idno type="wicri:Area/Ncbi/Merge">000D79</idno><idno type="wicri:Area/Ncbi/Curation">000D79</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D79</idno><idno type="wicri:doubleKey">1879-6257:2017:Corti D:tackling:influenza:with</idno><idno type="wicri:Area/Main/Merge">000268</idno><idno type="wicri:Area/Main/Curation">000268</idno><idno type="wicri:Area/Main/Exploration">000268</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tackling influenza with broadly neutralizing antibodies</title><author><name sortKey="Corti, Davide" sort="Corti, Davide" uniqKey="Corti D" first="Davide" last="Corti">Davide Corti</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Humabs BioMed SA, 6500 Bellinzona, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Humabs BioMed SA, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Cameroni, Elisabetta" sort="Cameroni, Elisabetta" uniqKey="Cameroni E" first="Elisabetta" last="Cameroni">Elisabetta Cameroni</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Humabs BioMed SA, 6500 Bellinzona, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Humabs BioMed SA, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Guarino, Barbara" sort="Guarino, Barbara" uniqKey="Guarino B" first="Barbara" last="Guarino">Barbara Guarino</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Humabs BioMed SA, 6500 Bellinzona, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Humabs BioMed SA, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author><author><name sortKey="Kallewaard, Nicole L" sort="Kallewaard, Nicole L" uniqKey="Kallewaard N" first="Nicole L" last="Kallewaard">Nicole L. Kallewaard</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhu, Qing" sort="Zhu, Qing" uniqKey="Zhu Q" first="Qing" last="Zhu">Qing Zhu</name><affiliation wicri:level="2"><nlm:aff id="aff0010">Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Disease, MedImmune, Gaithersburg, MD 20878</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona</wicri:regionArea><wicri:noRegion>6500 Bellinzona</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current Opinion in Virology</title><idno type="ISSN">1879-6257</idno><idno type="eISSN">1879-6265</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Broadly neutralizing antibodies against influenza A and B represents a safe and affordable alternative to convalescent plasma.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">The large majority of broadly neutralizing antibodies target the stem region of HA.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Antiviral protection by anti-HA antibodies comprises both Fab- and Fc-dependent mechanisms.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Several broadly neutralizing antibodies are in development for the therapy of severe influenza infections.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thompson, W W" uniqKey="Thompson W">W.W. 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Delaney</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suisse</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Suisse"><noRegion><name sortKey="Corti, Davide" sort="Corti, Davide" uniqKey="Corti D" first="Davide" last="Corti">Davide Corti</name></noRegion><name sortKey="Cameroni, Elisabetta" sort="Cameroni, Elisabetta" uniqKey="Cameroni E" first="Elisabetta" last="Cameroni">Elisabetta Cameroni</name><name sortKey="Guarino, Barbara" sort="Guarino, Barbara" uniqKey="Guarino B" first="Barbara" last="Guarino">Barbara Guarino</name><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Kallewaard, Nicole L" sort="Kallewaard, Nicole L" uniqKey="Kallewaard N" first="Nicole L" last="Kallewaard">Nicole L. Kallewaard</name></region><name sortKey="Zhu, Qing" sort="Zhu, Qing" uniqKey="Zhu Q" first="Qing" last="Zhu">Qing Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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